loading page

Diffusion tensor imaging of renal parenchyma in pediatric patients with chronic kidney disease: Correlation with serum biomarkers
  • +4
  • Ahmed Abdel Razek,
  • Ayman Hammad,
  • Manar Mansour,
  • Marwa Ramadan,
  • Khadiga Ali,
  • Dina Ibrahim,
  • Tarek Barakat
Ahmed Abdel Razek
Mansoura University Faculty of Medicine
Author Profile
Ayman Hammad
Author Profile
Manar Mansour
Author Profile
Marwa Ramadan
Author Profile
Khadiga Ali
Author Profile
Dina Ibrahim
Author Profile
Tarek Barakat
Author Profile

Abstract

Purpose: to demonstrate role of diffusion tensor imaging (DTI) in diagnosis of pediatric chronic kidney disease (CKD) using fraction anisotropy (FA) and apparent diffusion coefficient (ADC). Material and methods: Prospective study done on 35 CKD patients (19 boys, 16 girls; mean age 12.2±2.7 years) and 19 age and sex-matched volunteers. Patients with sclerotic (n = 25) and non-sclerotic (n= 10) CKD that underwent DTI of kidney. Results: Mean FA of renal cortex/ medulla in CKD (0.20±0.07, and 0.18±0.08) was significantly lower (p = 0.001) from volunteers (0.27±0.08, 0.31±0.09). Cutoff renal FA of cortex/ medulla used for diagnosis of CKD was 0.23, and 0.22 with AUC of 0.828, 0.828 and accuracy of 82.9%, 80.7%. Mean ADC of renal cortex/ medulla in CKD (1.98±0.23 and 2.03±0.23 X10-3mm2/s) was significantly higher (p = 0.001) that of volunteers (1.65±0.134 and 1.68±0.16 X10-3mm2/s. Cutoff renal ADC of cortex/medulla used to diagnosis of CKD were 1.75 and 1.85X10-3mm2/s with AUC of 0.828, 0.910, 0.828 and 0.81 and accuracy of 82.9%, 84.1%, 80.7% and 79.5%. FA of renal cortex/medulla in sclerotic CKD was significantly different (p = 0.001) than non-sclerotic CKD (0.26±0.07 and 0.25±0.08). The FA of renal cortex/medulla in CKD patients correlated with serum creatinine (r = -0.468; p = 0.000, r =-0.381; p = 0.001), e GFR (r = 0.364; p = 0.002, r = 0.318; p = 0.007). Conclusion: FA and ADC of renal cortex/ medulla can help in diagnosis of CKD, FA cortex/ medulla predicts sclerotic CKD and correlated with some of serum biomarkers.