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Dynamic thiol-disulphide homeostasis in the etiopathogenesis of obstructive jaundice
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  • Fadime Gullu Haydar,
  • Yavuz Otal,
  • GAMZE AVCIOĞLU,
  • Alp Şener,
  • Selda Kidak Ozkaya,
  • Yunus halil Polat,
  • Şervan Gökhan,
  • Özcan Erel
Fadime Gullu Haydar
Ankara City Hospital
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Yavuz Otal
Ankara City Hospital
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GAMZE AVCIOĞLU
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Alp Şener
Ankara Yildirim Beyazit University Faculty of Medicine
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Selda Kidak Ozkaya
Ankara City Hospital
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Yunus halil Polat
Ankara City Hospital
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Şervan Gökhan
Ankara Yildirim Beyazit University Faculty of Medicine
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Özcan Erel
Ankara Yildirim Beyazit Universitesi Tip Fakultesi
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Abstract

ABSTRACT Background:Metabolic changes seen after obstructive jaundice increase the load of oxidative stress.The thiol-disulphide homeostasis (TDB) has a vital importance as oxidatice stress biomarker. Aim: The aim of present study is to investigate the dynamic thiol-disulphide homeostasis in patients diagnosed with obstructive jaundice and to compare the dynamic thiol-disulphide homeostasis with ischemia modified albumin. Study design: A total of 146 participants who were admitted to emergency department and who consisted of 69 patients and 77 healthy volunteers, were included in the study. Detailed blood samples were obtained from the patients at the time of admission. Methods: Thiol / disulphide levels were examined using a novel method developed by Erel and Neselioglu on the patients diagnosed with obstructive jaundice during the admission. Data were evaluated in computer system. Results: The levels of total thiol (p =0.025) and native thiol (p =0.023) were statistically significantly lower in the patient with obstructive jaundice than in the control group. It was observed that there was a significant negative correlation between the native thiol levels and the ALP (r =-0.262, p<0.01), urea (r =-0.313, p<0.01), total bilirubin (r =-0.388, p<0.01), direct bilirubin (r =-0.351, p<0.01) levels. At the same time, the level of disulphide (p = 0.235) was lower in the patient group than in the control group but not statistically significant. It was found that the ischemia modified albumin (IMA) values were lower in the control group than the obstructive jaundice group (p = 0.03). Conclusion: Total thiol, native thiol and IMA levels decrease in obstructive jaundice pathogenesis.