loading page

Ketamine as a Sedative for Methotrexate-Induced Neurotoxicity with Added NMDA Antagonism
  • +4
  • Zara Ilahi,
  • Shruthi Janardhan,
  • Manasi Dave,
  • Megan Khariton,
  • Pamela Feuer,
  • Akila Venkataraman,
  • Eleny Romanos-Sirakis
Zara Ilahi
Staten Island University Hospital
Author Profile
Shruthi Janardhan
Staten Island University Hospital
Author Profile
Manasi Dave
Staten Island University Hospital
Author Profile
Megan Khariton
Staten Island University Hospital
Author Profile
Pamela Feuer
Staten Island University Hospital
Author Profile
Akila Venkataraman
Staten Island University Hospital
Author Profile
Eleny Romanos-Sirakis
Staten Island University Hospital
Author Profile

Abstract

MTX is used in the treatment of several childhood cancers and has side effects of varying severity [1]. Neurotoxicity can occur in up to 15% of patients receiving high-dose MTX [2, 3]. Elevated homocysteine in CSF are documented in such cases. Dextromethorphan, an NMDA receptor antagonist, suppresses homocysteine activity and is the initial treatment. Ketamine, also an NMDA receptor antagonist, may be considered as an optimal treatment choice in intubated patients requiring sedation. We describe the use of ketamine in a pediatric patient with methotrexate-induced neurotoxicity. Ketamine as treatment of MTX-induced neurotoxicity has not been described in the literature.