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Neuroimaging findings in MOGAD -- MRI and OCT
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  • Frederik Bartels,
  • Angelo Lu,
  • Frederike Oertel,
  • Carsten Finke,
  • Friedemann Paul,
  • Claudia Chien
Frederik Bartels
Charité Universitätsmedizin Berlin
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Angelo Lu
Max-Delbruck-Centrum fur Molekulare Medizin in der Helmholtz-Gemeinschaft
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Frederike Oertel
Max-Delbruck-Centrum fur Molekulare Medizin in der Helmholtz-Gemeinschaft
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Carsten Finke
Charité Universitätsmedizin Berlin
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Friedemann Paul
Max-Delbruck-Centrum fur Molekulare Medizin in der Helmholtz-Gemeinschaft
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Claudia Chien
Max-Delbruck-Centrum fur Molekulare Medizin in der Helmholtz-Gemeinschaft
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Abstract

Summary Myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord, optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and imaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how these imaging methods have led to recent insights for consideration in future studies.

Peer review status:UNDER REVIEW

28 Feb 2021Submitted to Clinical & Experimental Immunology
01 Mar 2021Submission Checks Completed
01 Mar 2021Assigned to Editor
09 Mar 2021Reviewer(s) Assigned
19 Apr 2021Review(s) Completed, Editorial Evaluation Pending
22 Apr 2021Editorial Decision: Revise Minor
25 May 20211st Revision Received
26 May 2021Reviewer(s) Assigned
08 Jun 2021Review(s) Completed, Editorial Evaluation Pending
08 Jun 2021Editorial Decision: Revise Minor
14 Jun 20212nd Revision Received
14 Jun 2021Reviewer(s) Assigned