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Risk factors associated with Diabetes Mellitus in COVID-19 infected patients: A meta-analytic synthesis of observational studies
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  • Upasna Gaba,
  • Mohammad Altamish,
  • Md Azharuddin,
  • Mohammad Adil,
  • Pinaki Ghosh,
  • Bishal Gyawali,
  • Manju Sharma
Upasna Gaba
Manipal Academy of Higher Education
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Mohammad Altamish
School of Pharmaceutical Education and Research, Jamia Hamdard,
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Md Azharuddin
School of Pharmaceutical Education and Research, Jamia Hamdard
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Mohammad Adil
School of Pharmaceutical Education and Research, Jamia Hamdard
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Pinaki Ghosh
Bharati Vidyapeeth Deemed University Poona College of Pharmacy
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Bishal Gyawali
Global Health Section, University of Copenhagen
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Manju Sharma
Jamia Hamdard
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Abstract

Aims: We carried out a systematic literature review and meta-analytic synthesis to find out association between DM and related outcomes in patients with COVID-19 infection. Methods: We systematically searched MEDLINE, and Web of Science to identify studies investigating comorbidities, clinical manifestations and resource utilization of diabetic patients exposed with COVID-19 published from inception to January 2021. Meta-analysis was carried out using Review Manager 5.3. Random effects model was used to compute the pooled estimates of odds ratio/mean difference (OR)/(MD) and 95% confidence intervals (CI). Results: Results from the pooled meta-analysis found that CVD, hypertension, AKI, cerebrovascular disease, AKI and ARDS were significantly associated with DM in COVID-19 infected patients compared to non-diabetic patients. There is significant association found between mortality and DM compared to non-diabetic patients [OR (95% CI): 2.46 (1.68, 3.58)]. ICU admission and use of mechanical ventilation was significantly associated with DM and COVID-19 vs. non-diabetic [OR (95% CI): 2.79 (1.79,4.34) and 3.33 (2.05, 5.42)] respectively. However, LOS, hospitalization, and ICU admission were not significantly differing between diabetes vs. non-diabetes. Conclusions: The results showed a significant association between mortality and DM exposed with COVID-19. Other co-morbidities especially CVD/hypertension could be a serious threat for DM COVID-19 infected patients for the higher mortality.

Peer review status:UNDER REVIEW

25 Mar 2021Submitted to International Journal of Clinical Practice
26 Mar 2021Assigned to Editor
26 Mar 2021Submission Checks Completed
27 Mar 2021Reviewer(s) Assigned