loading page

Comparison of the N-Terminal pro-Brain Natriuretic Peptide Levels, Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte and Platelet-to-Lymphocyte Ratios Between the Patients with COVID-19 and Healthy Subjects; Are the Patients with COVID-19 Under the Risk of Cardiovascular Events?
  • +4
  • Özgür Altınbaş,
  • İbrahim Halil Ertaş,
  • Ayşe Özlem Mete,
  • Şeniz Demiryürek,
  • Erhan Hafız,
  • Ahmet Saracaloğlu,
  • Abdullah Tuncay Demiryürek
Özgür Altınbaş
Gaziantep University
Author Profile
İbrahim Halil Ertaş
Dr Ersin Arslan Training and Research Hospital
Author Profile
Ayşe Özlem Mete
Gaziantep University
Author Profile
Şeniz Demiryürek
Gaziantep University
Author Profile
Erhan Hafız
Gaziantep University
Author Profile
Ahmet Saracaloğlu
Gaziantep University
Author Profile
Abdullah Tuncay Demiryürek
Gaziantep University
Author Profile

Abstract

Backround: The ongoing pandemic of Coronavirus Disease 2019 (COVID-19) infection has declared as a global emergency. Although the most people had mild illness due to the infection, some patients were seriously affected associated with complications especially including respiratory and cardiovascular systems. In despite of the respiratory system involvement is in the foreground, cardiovascular complications result in worse clinical outcomes. The purpose of this study is to compare the levels of the N-terminal pro-brain natriuretic peptide, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios -which are accepted as a marker of negative outcomes in cardiovascular diseases- of the patients with COVID-19 and healthy subjects and reveal the increased risk of cardiovascular disease in patients with COVID-19. Methods: This prospective study was designed in a single center and included 33 patients with COVID-19 (Group 1) and 33 healthy subjects consisted of health care professionals (Group 2). N-terminal pro-brain natriuretic peptide levels, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios were compared between the groups. Results: N-terminal pro-brain natriuretic peptide levels, neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were statistically significantly higher in the patients with COVID-19 (p<0,0001) and lymphocyte-to-monocyte ratio was statistically significantly lower in the same group (p<0,0001). Conclusion: Cardiovascular manifestations result in worse outcomes in patients with COVID-19 although the disease primarily affects the respiratory system. Early detection of this clinical situation and taking precautions have vital importance in the progress of the disease. NT-proBNP levels, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios are inexpensive, easy, fast and reproducible parameters that can be used in determination of probabl cardiovascular events that may develop during COVID-19 and enables early optimal treatment strategies for patients.