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Diaphragm Ultrasography to Predict Respiratory Failure in Infants with Severe Bronchiolitis
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  • Ana Gómez-Zamora,
  • Diego Rodriguez-Alvarez,
  • Iria Durán-Lorenzo,
  • Cristina Schüffelmann,
  • Miguel Rodríguez-Rubio ,
  • Paloma Dorao Martinez-Romillo
Ana Gómez-Zamora
La Paz University Hospital Children Hospital
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Diego Rodriguez-Alvarez
La Paz University Hospital Children Hospital
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Iria Durán-Lorenzo
Great Ormond Street Hospital for Children
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Cristina Schüffelmann
La Paz University Hospital Children Hospital
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Miguel Rodríguez-Rubio
Hospital Universitario La Paz
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Paloma Dorao Martinez-Romillo
La Paz University Hospital Children Hospital
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Objetive: To evaluate the ultrasonographic contractile activity indices of the diaphragm in infants with moderate and severe bronchiolitis supported with high-flow nasal cannula (HFNC) or non-invasive ventilation (NIV) to predict the need of invasive mechanical ventilation (IMV). Methods: Prospective observational study in infants admitted to a Pediatric Intensive Care Unit (PICU). Diaphragmatic excursion (dEx), diaphragmatic inspiratory (dTi) and expiratory time (dTe), and fraction of diaphragmatic thickening (dTF) were recorded at admission, 24 h and 48 h in both diaphragms. RESULTS: Twenty-six patiens were included (14 on HFNC and 12 on NIV) with a total of 56 ultrasonographic evaluations. Three patients required IMV. Sixty-four percent of the patients on HFNC required NIV as rescue therapy and 2/14 IMV (14,2%). In the HFNC group there were no differences in dEx between those who required escalation to NIV or IMV and those who didn’t. Diaphragmatic left thickening fraction (Left dTF) increased in patients on HFNC requiring IMV vs those needing NIV (Left dTF 47% vs 22% (13-30); p=0,046, r=0,7) (Fig 2). Diaphragmatic inspiratory time was higher in infants on HFNC requiring IMV and diaphragmatic expiratory time was shorter (dLET, p=0,038; dRET, p=0,022). In the NIV group there were no diffenreces in dEx, dTi, dTe or dTF between patients needing escalation to IMV and those who didn’t. We found no correlation between a clinical score and echographic dTF. CONCLUSION: In infants with moderate or severe brochiolitis receiving HFNC the use of ultrasonographic left dTF could help predict respiratory failure (RF) and need for IMV. The use of ultrasonographic diaphragmatic excursion is of little help to predict both.

Peer review status:UNDER REVIEW

03 Apr 2021Submitted to Pediatric Pulmonology
05 Apr 2021Assigned to Editor
05 Apr 2021Submission Checks Completed
07 Apr 2021Reviewer(s) Assigned