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Improved function and balance in T cell modulation by endothelial cells in young people
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  • Shu-Qian Tang,
  • Wei-Li Yao,
  • Yazhe Wang,
  • Yuan-Yuan Zhang,
  • Hong-Yan Zhao,
  • Qi Wen,
  • Yu Wang,
  • Lan-Ping Xu,
  • Xiao-hui Zhang,
  • Xiaojun Huang,
  • Yuan Kong
Shu-Qian Tang
Peking University People's Hospital
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Wei-Li Yao
Peking University People's Hospital
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Yazhe Wang
Peking University People's Hospitial
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Yuan-Yuan Zhang
Peking University People's Hospital
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Hong-Yan Zhao
Peking University People's Hospital
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Qi Wen
Peking University People's Hospital
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Yu Wang
Peking University People's Hospital, Peking University Institute of Hematology,
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Lan-Ping Xu
Peking University People’s hospital
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Xiao-hui Zhang
Peking University People's Hospital, Peking University Institute of Hematology,
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Xiaojun Huang
Peking University People's Hospital
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Yuan Kong
Peking University People's Hospital
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Abstract

Elderly individuals exhibit unbalanced bone marrow (BM) effector T cell subset differentiation, such as increased T helper (Th)-1 and T cytotoxic (Tc)-1 cell frequencies, but the underlying mechanism still unclear. Endothelial cells (ECs) , which are instructive components of the BM microenvironment, exhibit the phenotype of semi-professional antigen-presenting cells and regulate T cell recruitment and activation. Thus, we compared the frequency and function of BM ECs, especially their capacity to regulate effector T cell subsets, between young and old healthy individuals, and explored the underlying mechanism of this immunomodulatory discrepancy. Although the young and old EC percentages were comparable, young ECs showed less reactive oxygen species and better migratory and tube-forming abilities than old ECs. Notably, young ECs regulated T cells to differentiate into fewer Th1 and Tc1 cells than old ECs. Reduced T cell activation molecules and inflammatory cytokines in young BM ECs may be the possible mechanism.

Peer review status:UNDER REVIEW

18 May 2021Submitted to Clinical & Experimental Immunology
19 May 2021Assigned to Editor
19 May 2021Submission Checks Completed
07 Jun 2021Reviewer(s) Assigned