A decreased prevalence of group 2 innate lymphoid cells in blood is
associated with good postoperative outcomes in patients with chronic
rhinosinusitis
Abstract
Objectives: The aim of this study was to investigate whether the
prevalence of group 2 innate lymphoid cells (ILC2s) in sinonasal tissues
or in peripheral blood is associated with the postoperative outcome in
chronic rhinosinusitis (CRS) patients. Design: A cross-sectional study
of CRS patients undergoing endoscopic sinus surgery (ESS). Setting: The
Department of Otorhinolaryngology-Head and Neck Surgery at Shiga
University of Medical Science Hospital. Participants: Eleven patients
with eosinophilic CRS (eCRS) and ten patients with non-eCRS were
recruited. Main outcome measures: We examined the ILC2 prevalence in
sinonasal tissues and in peripheral blood before and after ESS.
Lund-Mackay computed tomography (LMK-CT) scores were used to evaluate
the postoperative outcomes; cases with more than 50% improvement were
categorized into the good outcome group, and cases with less than 50%
improvement were categorized into the poor outcome group. Results: The
ILC2 prevalence in sinonasal tissues was correlated with that in
preoperative blood in the eCRS and non-eCRS patients. The ILC2
prevalence in sinonasal tissues and in preoperative blood was not
correlated with the pre- or postoperative LMK-CT scores.
Postoperatively, the ILC2 prevalence in blood was decreased in the eCRS
and non-eCRS patients, and the decrease was associated with the good
outcome group, but not the poor outcome group. Conclusion: The decreased
ILC2 prevalence in blood may be related to good postoperative outcomes
after ESS in eCRS and non-eCRS patients.