Anti-atherosclerosis mechanisms associated with regulation of non-coding
RNAs by active monomers of traditional Chinese medicine
Abstract
Atherosclerosis is the leading cause of numerous cardiovascular diseases
with a high mortality rate. Non-coding RNAs (ncRNAs), RNA molecules that
do not encode proteins in human genome transcripts, are known to play
crucial roles in various physiological and pathological processes.
Recently, researches on the regulation of atherosclerosis by ncRNAs,
mainly including microRNAs, long non-coding RNAs, and circular RNAs,
have gradually become a hot topic. Traditional Chinese medicine has been
proved to be effective in treating cardiovascular diseases in China for
a long time, and its active monomers have been found to target a variety
of atherosclerosis-related ncRNAs. These active monomers of traditional
Chinese medicine hold great potential as drugs for the treatment of
atherosclerosis. Here, we summarized current advancement of the
molecular pathways by which ncRNAs regulates atherosclerosis and mainly
highlighted the mechanisms of traditional Chinese medicine monomers in
regulating atherosclerosis through targeting ncRNAs.