Objectives Aim of this study was to investigate clinical characteristics and individualized treatment experience of different types of deep neck space infections(DNSI) . Design Retrospective study. Setting Tertiary Referral Otolaryngology Centre. Participants 51 subjects with deep neck space infections. Main outcome measures In 51 subjects with DNSI, 15 cases were not treated with abscess incision and drainage; 36 cases were treated by incision, drainage and dressing change: 23 cases were treated with traditional incision and drainage and dressing change; 13 cases were given the combined treatment of incision and drainage, pyogenic cavity aerobic therapy and negative pressure drainage. The average number of days of dressing change and average hospital stay were compared between the two groups Results The average hospitalization days in the traditional dressing group were (26.74±3.393) days, and the average days of postoperative dressing change were (25.91±3.427) days. The average hospitalization days in pyogenic cavity aerobic therapy + negative pressure drainage were (11.08±2.108) days, and the average days of postoperative dressing change were (3.692±0.208) days. All 51 patients were cured. Conclusion Individualized treatment can minimize the trauma of patients according to each patient’s own situation. The pyogenic cavity aerobic therapy has proved to be a good method for dressing change after deep neck space infections, and the satisfactory curative effect.