Prostate cancer and benign prostatic hyperplasia (BPH) are two common diseases of the prostate gland. Pharmaceutical drugs are widely used to treat BPH, which enhance symptoms but are also accompanied by side effects such as erectile dysfunction, which have a negative impact on quality of life. Prostate cancer, like other cancers, has a wide range of treatment options. The effectiveness of these prostate cancer therapies is determined by the stage of the disease. While the efficacy of prostate cancer therapies varies, erectile dysfunction, incontinence, and a lower quality of life are all common side effects. Diet and lifestyle factors can be helpful in lowering the risk of cancer, according to preliminary evidence from systematic reviews. Lycopene, a carotenoid found in a variety of red-colored fruits and vegetables, has been shown to have powerful antioxidant and pro-oxidant properties. The existing evidence on the use of lycopene as a prostate disease prevention agent is examined in this chapter.