Achieving the building’s sustainability requires the assessment of its life-cycle, involving the selection of sustainable materials during the construction stage and adopting rooftop PV system in the exploitation stage, with the objective to lower its carbon footprint. This paper reports a case study for the design of a sustainable office building, located out of town, integrating PV panels for autonomous electricity production. For this purpose, the multi criteria decision making analysis was carried out to select the optimum sustainable materials, and the energetic balance of the building was evaluated. Accordingly, the required rooftop PV panels and the associated area were then estimated, while a storage battery was included for the building’s continuous electrical supply. Using the Weighting Sum Method, and considering the technical/environmental and financial constraints, double wall in hollow brick and expanded polystyrene floor were selected, while expanded polystyrene was used as the insulating material. The energetic analysis of the building performances indicated an average annual heating and air cooling requirement of 0.57 kWh/m ² and 36.87 kWh/ m ², respectively. Finally, the on-roof PV panels required a nominal peak power of 400kWp with 1218m ² area, while a 82kAh storage battery capacity was evaluated for a continuous electricity production.