loading page

The association of PCOS and hypertensive disorders of pregnancy -a community based approach
  • +9
  • Juhani Rantakallio,
  • Jaana Nevalainen,
  • Sammeli West,
  • Meri-Maija Ollila,
  • Katri Puukka,
  • Aini Bloigu,
  • Marjoriitta jarvelin,
  • Juha Tapanainen,
  • Stephen Franks,
  • Terhi Piltonen,
  • Marja Vääräsmäki ,
  • Laure Morin-Papunen
Juhani Rantakallio
Oulu University Hospital
Author Profile
Jaana Nevalainen
Oulu University Hospital
Author Profile
Sammeli West
Oulu University Hospital
Author Profile
Meri-Maija Ollila
Oulu University Hospital
Author Profile
Katri Puukka
Oulu University Hospital
Author Profile
Aini Bloigu
Oulu University Hospital
Author Profile
Marjoriitta jarvelin
MRC-PHE Centre for Environment and Health
Author Profile
Juha Tapanainen
University of Oulu
Author Profile
Stephen Franks
Institute of Reproductive and Developmental Biology
Author Profile
Terhi Piltonen
University of Oulu
Author Profile
Marja Vääräsmäki
University of Oulu
Author Profile
Laure Morin-Papunen
Oulu University Hospital
Author Profile

Abstract

OBJECTIVE To investigate the prevalence of hypertensive disorders of pregnancy (HDP), and the roles of polycystic ovary syndrome (PCOS), obesity, weight gain (WG) and hyperandrogenaemia in the development of HDP by age 46. DESIGN prospective population-based cohort. Setting and population The Northern Finland Birth Cohort 1966 (NFBC1966) METHODS Follow-up at ages 14, 31 and 46, including women with (n=408) and without (n=3373) HDP. HDP was combined from the questionnaire data at age 46, hospital discharge records and Finnish Medical Birth Registers. Women with both oligo-amenorrhea and hirsutism at age 31 and/or with PCOS diagnosis by age 46 (self-reported PCOS, srPCOS, n=279) were compared with women without symptoms or PCOS diagnosis (n=1577). Main outcome measures Association of PCOS and WG through life with HDP RESULTS Women with srPCOS had an increased HDP risk ([OR]=1.56 [95%CI:1.03-2.37]), but the association disappeared after BMI adjusting at age 31. Increase of BMI from age 14 to 31 was significantly greater in srPCOS (median [interquartile range]:5.94kg/m2[3.69;11.1], p<0.001) and non-PCOS (4.89kg/m2[3.21;7.57], p<0.001) women with HDP and in srPCOS women without HDP (4.59kg/m2[2.40;7.54], p=0.009) compared to non-PCOS without HDP. Among women with srPCOS, BMI increase was greater in women with than without HDP (5.94kg/m2 [3.69;11.1] vs 4.59kg/m2[2.40;7.54], p=0.015). Hyperandrogenaemia at 31 or 46 did not associate with HDP (OR=1.44[95%CI: 0.98-2.11]). CONCLUSION Obesity and weight gain from adolescence to age 46, but not srPCOS or hyperandrogenaemia, were associated with an increased risk of HDP.