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Gene differentiation, reassortment, and evolution of H5N6 Avian influenza virus in China during 2016-2019
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  • xiao Li,
  • jianglin Chen,
  • jing Liu,
  • lezi Yin,
  • shumin Xie,
  • mengmeng Zhang,
  • meifeng Liang,
  • siru Lin,
  • yiqi Liao,
  • xuanjiang Jin,
  • jingkai Hu,
  • jinfeng Wang,
  • yifan Wu,
  • wenbao qi,
  • Ming Liao,
  • weixin Jia
xiao Li
SCAU
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jianglin Chen
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jing Liu
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lezi Yin
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shumin Xie
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mengmeng Zhang
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meifeng Liang
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siru Lin
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yiqi Liao
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xuanjiang Jin
SCAU
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jingkai Hu
SCAU
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jinfeng Wang
SCAU
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yifan Wu
SCAU
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wenbao qi
SCAU
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weixin Jia
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Abstract

Continuous monitoring and analysis of the evolution, recombination and epidemic of avian influenza virus will help to prevent and control the emergence of new avian influenza virus. The genes of 153 H5N6 avian influenza viruses selected from our long-term surveillance data and the GISAID for the 2016-2019 period were dissected in detail. Our analysis shows that the genes of H5N6 AIVs have been divided into more lineages, and that mutations leading to amino acid replacement of hemagglutinin and neuraminidase occurred mainly between 2017 and 2018. All H5N6 viruses are differentiated into at least 20 distinct genotypes derived from different evolutionary pathways. G1 genotype has replaced other genotypes to become dominant genotype of AIV. The results of animal experiments show that H5N6 of different genotypes has high virulence to mice. which indicates that H5N6 AIVs, especially the reassortment strains, are a potential threat to public health.