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Tinnitus severity correlated with zinc, copper, risk factors: a large-scale case-control study
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  • Jiangfeng Huang,
  • Jing He,
  • Qingping Zhu,
  • Zhiwei Zheng,
  • Peiji Zeng,
  • Wei Liu,
  • Jing Gao,
  • Hanjing Shangguan,
  • Xianyang Luo,
  • Chengfu Cai,
  • Dongyan Shen,
  • Jinxing Shen,
  • Mingqiang Lin,
  • Dong Mei Tang,
  • Huawei Li,
  • Baochang He,
  • Lin Cai
Jiangfeng Huang
Xiamen University and Fujian Medical University Affiliated First Hospital
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Jing He
Xiamen University and Fujian Medical University Affiliated First Hospital
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Qingping Zhu
Xiamen University and Fujian Medical University Affiliated First Hospital
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Zhiwei Zheng
Xiamen University and Fujian Medical University Affiliated First Hospital
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Peiji Zeng
Xiamen University and Fujian Medical University Affiliated First Hospital
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Wei Liu
Xiamen University and Fujian Medical University Affiliated First Hospital
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Jing Gao
Xiamen University and Fujian Medical University Affiliated First Hospital
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Hanjing Shangguan
Xiamen University and Fujian Medical University Affiliated First Hospital
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Xianyang Luo
Xiamen University and Fujian Medical University Affiliated First Hospital
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Chengfu Cai
Xiamen University and Fujian Medical University Affiliated First Hospital
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Dongyan Shen
Xiamen University and Fujian Medical University Affiliated First Hospital
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Jinxing Shen
Xiamen University and Fujian Medical University Affiliated First Hospital
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Mingqiang Lin
Xiamen University and Fujian Medical University Affiliated First Hospital
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Dong Mei Tang
Fudan University Eye Ear Nose and Throat Hospital
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Huawei Li
Fudan University Eye Ear Nose and Throat Hospital
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Baochang He
Fujian Medical University
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Lin Cai
Fujian Medical University
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Peer review status:UNDER REVIEW

23 Apr 2020Submitted to Clinical Otolaryngology
24 Apr 2020Assigned to Editor
24 Apr 2020Submission Checks Completed
28 Apr 2020Review(s) Completed, Editorial Evaluation Pending

Abstract

Objectives This large-scale case-control study aimed to explore the trace elements (Zn & Cu) and risk factors associated with tinnitus severity (mild and moderate-to-severe tinnitus).
Methods The serum levels of Zn & Cu of participants were measured by inductively coupled plasma mass spectrometry (ICP-MS). The potential risk factors were analyzed by simple and multiple logistic regression analysis.
Results Compared mild tinnitus with moderate-to-severe tinnitus, the serum Zn of participants had a significant difference (P=0.05), and only the age variable displayed an evident difference in main clinical characteristics analysis table (P<0.05). Under a multivariable-adjusted analysis, the potential risk factors included hearing loss (AOR: 1.704, 95% CI: 1.009-2.880), HADS-A (borderline abnormal, AOR: 2.876, 95% CI: 1.248-6.625; abnormal, AOR: 12.149, 95% CI: 2.722-54.218), AIS (slight sleep problems, AOR: 2.030, 95% CI: 1.061-3.885; probable/definite insomnia, AOR: 6.955, 95% CI: 3.669-13.185), ear-self-cleaning (<1 t/w, AOR: 2.117, 95% CI: 1.178-3.805; 3-6 t/w, AOR: 2.462, 95% CI: 1.081-5.607; ≥7 t/w, AOR: 2.472, 95% CI: 1.041-5.868), tea consumption (AOR: 1.138, 95% CI: 1.052-1.231) and sleep apnea (AOR: 1.805, 95% CI: 1.036-3.145). Next, a stratified analysis was made on these risk factors, and the results showed that the low levels of Zn were significantly associated with tinnitus severity in hearing loss group——both in “no” and “yes” subgroups (“no”, AOR: 2.588, 95% CI: 1.348-6.061; “yes”, AOR: 4.213, 95% CI: 1.106-8.430), and in HADS-A group——noly in “normal” subgroup (AOR: 2.928, 95% CI: 1.790-6.984).
Conclusions Serum Zn deficiency and potential risk factors (including hearing loss, tea consumption, sleep apnea, anxiety, insomnia and ear-self-cleaning habit) were significantly correlated with tinnitus severity. Intervention with these risk factors could prevent the mild tinnitus from becoming moderate-to-severe tinnitus.