Introduction: WHO has considered Major Congenital Anomalies (MCA) as a
recognizable cause of morbidity and mortality in infants and children
under five years of age. Method: This is a descriptive study of
antenatal MCA over 10 years period from January 2009 to December 2018.
All data were analyzed statistically using STATA software (Stata
Corporation, College Station, TX). Results: During the study period,
there were 147563 patients. Of which, 1502 cases found to have major
congenital anomalies, among them 947 (63.05 %) fetuses with isolated
major anomalies and 555 cases (36.95%) with MCA. The average antenatal
prevalence of MCA for 10 years was 10.1 per 1000 pregnancies. The mean
gestational age during the first visit was 27(5.5) weeks with range from
10 to 40 weeks. The maternal age was 30 (6.0) years. Coexisting maternal
factors were observed in 481 (32%) of patients including gestational
diabetes (8.8%), maternal age (6.59%) and recurrent early pregnancy
loss (7.12%). Nervous system was the most common (29%) abnormalities
observed and cardiothoracic system (24.9%) was the second most common.
Perinatal outcomes showed that 9.6 % had early neonatal death, 19% had
still births and 4 % had neonatal death. The perinatal mortality rate
was 32.6% among fetuses with major congenital anomalies. Conclusions:
The prevalence of major congenital anomalies in our papulation is double
the international figures. This study emphasizes the need of national
surveillance system and database for congenital anomalies and efforts
should be focused in rising awareness of the occurrence and risk factors
of congenital anomalies.