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No evidence of Re-infection or Person-to-Person Transmission in Cured COVID-19 Patients, a Retrospective Cohort Study
  • +10
  • Gang Xu,
  • Feng Liu,
  • Jun Zhao,
  • Min Ye,
  • Congrui Feng,
  • Yudong Hu,
  • Yuluo Chen,
  • Liuqian Wang,
  • Yueping Li,
  • Haiyan Shi,
  • Fuchun Zhang,
  • Yuwei Tong,
  • Wei Ma
Gang Xu
Guangzhou First People's Hospital
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Feng Liu
Guangzhou First People's Hospital
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Jun Zhao
Guangzhou First People's Hospital
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Min Ye
Guangzhou First People's Hospital
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Congrui Feng
Guangzhou First People's Hospital
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Yudong Hu
Guangzhou First People's Hospital
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Yuluo Chen
Guangzhou First People's Hospital
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Liuqian Wang
Guangzhou First People's Hospital
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Yueping Li
Guangzhou Eighth People's Hospital
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Haiyan Shi
Guangzhou Eighth People's Hospital
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Fuchun Zhang
Guangzhou Eighth People's Hospital
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Yuwei Tong
Guangzhou Eighth People's Hospital
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Wei Ma
Guangzhou First People's Hospital
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Abstract

Objectives To clarify the clinical features of cured patients with coronavirus disease (COVID-19) and the relevance of IgM and IgG testing. Methods A total of 187 cured COVID-19 patients with antibody test were followed up every two weeks. Assessment for general condition, symptoms, epidemiological contact history, polymerase chain reaction (PCR) assay, and antibody tests were performed and recorded. Information from Guangzhou CDC was also screened. Results The mean follow-up time was 45.7 days. There were 33 (17.6%) patients with negative results for IgG and 35 (18.7%) patients with positive results for IgM. PCR assay was positive in 10 (5.3%) patients during the follow-up. Neither IgG nor IgM results showed a relationship with PCR test results (all P > 0.05). Neither re-infection nor person-to-person transmission was found in the cured patients. Factors associated with appearance of antibody comprised hospitalization days (OR: 1.07, 95%CI: 1.02-1.13, P = 0.004) and antibiotics treatment (OR: 2.78, 95%CI: 1.10-7.01, P = 0.031) . Conclusions In our study, neither re-infection nor person-to-person transmission was found in cured patients with COVID-19. Additionally, neither IgG nor IgM can be used to replace the PCR test in cured patients.