Metabolic network of surfactin in Bacillus spp. and its challenge
Abstract
Surfactin, a kind of cyclic lipopeptide synthesized by non-ribosome
peptide synthases (NRPS) in Bacillus spp. strain, has attracted a great
deal of attention owing to its surface activity. It has broad prospect
of application in petroleum extraction, daily chemical, and clinical
treatment. To further improve the yield of surfactin, numerous studies
have focused on clarifying its metabolic network. Herein, this review
summarized essential modules in the metabolic network of surfactin,
including surfactin synthase, precursor supply, efflux pump system,
quorum sensing system, and biofilm formation. Furthermore, essential
genes proved by omics analysis and gene editing were emphasized. This
review aims to help understanding the intricate metabolic network of
surfactin and lay a foundation for reconstructing surfactin-overproduced
in whole system level.