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Clinical features and temporal changes of RT-PCR and chest CT in COVID-19 pediatric patients
  • +5
  • Wei Xia,
  • Yu Guo,
  • Zhiyao Tian,
  • Yan Luo,
  • Daoyu Hu,
  • Jianbo Shao,
  • Zhen Li,
  • Ihab R Kamel
Wei Xia
Wuhan Childrens Hospital
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Yu Guo
Wuhan Childrens Hospital
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Zhiyao Tian
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Yan Luo
Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology
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Daoyu Hu
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Jianbo Shao
Wuhan Childrens Hospital
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Zhen Li
Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology
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Ihab R Kamel
Russell H Morgan Department of Radiology & Radiological Sciences, Johns Hopkins Hospital, Johns Hopkins Med Inst
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Peer review status:UNDER REVIEW

09 Jun 2020Submitted to Pediatric Pulmonology
10 Jun 2020Assigned to Editor
10 Jun 2020Submission Checks Completed
11 Jun 2020Reviewer(s) Assigned
30 Jun 2020Review(s) Completed, Editorial Evaluation Pending

Abstract

Purpose: To investigate the clinical features and temporal changes of RT-PCR and CT in COVID-19 pediatric patients. Methods: Clinical, RT-PCR and CT features of 114 COVID-19 pediatric inpatients were retrospectively reviewed from January 21st to March 14th 2020. All patients had chest CT on admission and were identified as positive pharyngeal swab nucleic acid test. Clinical features were analyzed, as well as the features and temporal changes of RT-PCR and CT. Results: Fever (62, 54%) and cough (61, 54%) were the most common symptoms. There were 34 (30%) cases of concurrent infections. The most common imaging features on CT were ground-glass opacities (46, 40%) and consolidation (46, 40%). The bilateral lower lobes were the most common pattern of involvement, with 63 cases (55%) involving 1-2 lobes, and in 32 (28%) cases CT was normal. Through the whole duration of COVID-19 in children, the diagnostic positive rate of RT-PCR has been far higher than that of CT (All P<·05). For RT-PCR follow-up, reliable negative results were obtained only 7 days after the onset of symptoms. Though Lung involvement on chest CT progressed rapidly in several cases, lung involvement in children with COVID-19 is mild, with a median value of 2 on CT score. Conclusion: RT-PCR is more reliable than CT in initial diagnosis of pediatric patients with COVID-19. On follow up, reliable RT-PCR results are available 7 days after initial symptoms. Only if necessary, CT could be used for follow-up.