Abstract
Magnetic ferrite based nanoparticles (MFNPs) are becoming an interesting
candidate for nanomedicine development and found application in drug
delivery and diagnostics. In the present work, we have synthetized
various spinel ferrite nanoparticles (NPs) by hydrothermal technique (a
simple and cost effective technique). Different divalent metals, namely
Ni, Zn, Cu and Co, were used for spinel ferrite preparation. Since these
NPs are injected directly to the blood for therapeutic or diagnostic
purpose their influence on the composition of human blood serum once in
contact were investigated. The blood serum was analyzed by means of
Fourier transform infrared (FTIR) and UV- Visible absorption
spectroscopies. The results indicated the formation of protein-corona
with all studied MFPN’s. Small amount of metal oxides were found to be
released from the MFNP’s to the serum. Based on our study, ZnFe2O4 has
been suggested as the most suitable spinel ferrite NPs for Nano medicine
applications.