As you would be aware, COVID-19 has rapidly spread to a number of countries around the world. In our letter, we have reviewed chest imaging from a 36-year male with severe COVID-19. We found that his lung lesions started to gradually diminish after about a month. Besides, we found that invasive mechanical positive pressure ventilation had both positive and negative effects. Lung-protective ventilation strategies should be adopted and full attention given to iatrogenic injuries in the diagnosis and treatment of patients with COVID-19. This case report may have a significant impact on the clinical management of patients with COVID-19.