Aim of Study: The goal of this study was to evaluate ischemia-modified albumin (IMA) as a novel marker of oxidative stress in tuberculosis patients and to investigate changes occurring in patients. Methods: Our study included 50 patients with active lung tuberculosis and 48 healthy controls. Serum ischemia-modified albumin was measured with automated spectrometric method and results were compared statistically. Results: We found that IMA levels were significantly higher in pulmonary tuberculosis patients than in the control group. Albumin levels were significantly lower in the patient group than in the control group. Conclusion: The results of our study showed that we can use this parameter as a new oxidative stress marker in the pathogenesis of pulmonary tuberculosis. Evaluation of IMA and albumin parameters in patients with pulmonary tuberculosis may contribute significantly to the evaluation of these patients.