Effectiveness of Sucralfate comparing to normal saline as an oral rinse
in pain reduction and wound healing promotion in oral surgery
Abstract
Objectives: To study the effectiveness of Sucralfate suspension oral
rinse compared to normal saline alone for pain reduction and wound
healing promotion in open oral surgical wounds. The primary outcome of
this study was postoperative pain VAS score reduction. The secondary
outcome was wound healing promotion based on wound grade and maximal
wound length reduction Study Design: Randomized controlled trial
Setting: Department of Otolaryngology, King Chulalongkorn Memorial
Hospital Materials and Methods: A total of 30 patients with secondary
healing intraoral surgical wound were enrolled in this study. Sucralfate
suspension (1g/5ml) was prescribed to a randomized experimental group as
an oral rinse every 6 hours for 14 days in addition to standard
postoperative care. Postoperative pain VAS score, wound grade and wound
length were collected and compared with baseline from initial to final
visit during a 2-week period. Results: The mean change of VAS score was
significantly lower from baseline in the Sucralfate group at day3 (-0.77
in control and -2.15 in Sucralfate, p<0.05) and day 7 (-2.15
in control and -3.62 in Sucralfate, p<0.05). Wound grade
distribution over time was the same in both Sucralfate and control
groups. The mean change of wound length was not significantly different
between the two groups. No adverse reaction to Sucralfate was reported
during the study participation. Conclusions: Sucralfate suspension oral
rinse can be recommended as an effective topical analgesic solution in
postoperative secondary healing of intraoral wound with no significant
interference. Benefits to wound healing promotion have yet to be proven.
Keywords: Sucralfate, oral wound, oral surgery, pain, wound healing,
postoperative, analgesia