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Impact of malnutrition on the pharmacokinetics of chemotherapy in children with cancer: a systematic review
  • +4
  • Sterre Schoon,
  • Nthongase Makamo,
  • Aniek Uittenboogaard,
  • Brooke Bernhardt,
  • Nmazuo Ozuah,
  • Gertjan Kaspers,
  • Minke Huibers
Sterre Schoon
Prinses Maxima Centrum voor Kinderoncologie

Corresponding Author:[email protected]

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Nthongase Makamo
Baylor College of Medicine Department of Pediatrics
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Aniek Uittenboogaard
Prinses Maxima Centrum voor Kinderoncologie
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Brooke Bernhardt
Baylor College of Medicine Department of Pediatrics
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Nmazuo Ozuah
Baylor College of Medicine Department of Pediatrics
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Gertjan Kaspers
Prinses Maxima Centrum voor Kinderoncologie
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Minke Huibers
Prinses Maxima Centrum voor Kinderoncologie
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Abstract

Objectives This systematic review provides an overview of the effect of malnutrition on the pharmacokinetics of chemotherapy in children with cancer. Methods PubMed, Embase and Cochrane were searched to identify eligible studies. Malnutrition was referred to as undernutrition, as defined by the World Health Organisation and the Gomez Criteria. Results Four studies with a total of 668 children with cancer were included and n=121 (18%) were malnourished. In vincristine, the differences in pharmacokinetic parameters were statistically significant where clearance rates were commonly lower and area under the curve was increased in malnourished children. Conclusion The results are suggestive for pharmacokinetic alterations of chemotherapy in malnourished children with cancer. However, the data is scarce, groups are small, and most studies have been performed in high-income countries. Pharmacokinetic research among (severely) malnourished children with cancer is needed in order to improve their outcome, directed by sub-group and ultimately individualized drug dosing.
06 Feb 2023Submission Checks Completed
06 Feb 2023Assigned to Editor
06 Feb 2023Submitted to Pediatric Blood & Cancer
10 Feb 2023Review(s) Completed, Editorial Evaluation Pending
13 Feb 2023Reviewer(s) Assigned
13 Mar 2023Editorial Decision: Revise Major
02 Jun 20231st Revision Received
02 Jun 2023Submission Checks Completed
02 Jun 2023Assigned to Editor
02 Jun 2023Review(s) Completed, Editorial Evaluation Pending
05 Jun 2023Reviewer(s) Assigned
08 Jun 2023Editorial Decision: Revise Minor
12 Jun 2023Submission Checks Completed
12 Jun 2023Assigned to Editor
12 Jun 20232nd Revision Received
12 Jun 2023Review(s) Completed, Editorial Evaluation Pending
12 Jun 2023Reviewer(s) Assigned
16 Jun 2023Editorial Decision: Accept