Crop plants experience various abiotic stresses that reduce yield and quality. Although several adaptative physiological and defense responses to single stress have been identified, the behavior and mechanisms of plant response to multiple stresses remain underexamined. Herein, we determined that the leaf and vascular changes in CsIVP-RNAi cucumber plants can enhance resistance to nitrogen deficiency and high-temperature stress. CsIVP negatively regulated high nitrate affinity transporters (NRT2.1, NRT2.5) and reallocation transporters (NRT1.7, NRT1.9, NRT1.12) under low nitrogen stress. Furthermore, CsIVP-RNAi plants have high survival rate with low heat injury level under high temperature condition. CsIVP mediated key high-temperature regulators, including HSFs, HSPs, DREB2C, MBF1b, and WRKY33, in response to high temperature. Altogether, these results show that CsIVP integrates innate programming of plant development, nutrient transport, and high-temperature resistance, providing a potentially valuable target for breeding nutrient-efficient and heat-resistant crops. Identification or creation of elite alleles conferring optimal fruit production, nutrient use efficiency, and high-temperature resistance will bring tremendous scientific and economic benefits.