Analysis of risk factors for cervical insufficiency: a retrospective
controlled study
Abstract
Objective:To study the risk factors of cervical insufficiency (CI).
Design:Retrospective controlled study. Setting:First Hospital of
Shanxi Medical University. Population:209 CI patients with a singleton
pregnancy (CI group) and 348 patients randomly selected (control group).
Methods and main outcome measures:All patients were required to have
records of the whole pregnancy. The general conditions and pregnancy
complications of the two groups were collected. A model of logistic
regression and ROC curves were used. Results:Patients with a history of
multiple pregnancies had a 17.51 times higher risk of CI than negative
patients(OR=17.51, 95%CI: 2.16-141.85, P=0.007); patients who were
pregnant by IVF-ET/ovulation induction had a 3.26 times higher risk of
CI than negative patients(OR=3.26, 95%CI: 1.69-6.30,
P<0.001); patients with gestational diabetes (GDM) or
pregnancy with diabetes (PGDM) had a 2.88 times higher risk of CI than
negative patients(OR=2.88, 95%CI:1.87-4.44, P<0.001);
patients with PCOS had an 8.72 times higher risk of CI than negative
patients (OR=8.72, 95%CI: 2.33- 32.64, P=0.001); and patients with
uterine malformations had a 4.00 times higher risk of CI than negative
patients(OR=4.00, 95%CI:1.07-14.97, P=0.040) . The ROC curve showed
the combination of multiple indicators have a certain predictive ability
for CI (AUC=0.728). Conclusions:Previous multiple pregnancy,
IVF-ET/ovulation induction conception, diabetes mellitus (GDM or PGDM),
uterine malformations, and PCOS are risk factors for the incidence of
CI, and the combination of multiple indicators has some predictive
ability for CI. Funding:None