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Successful management with urgent haploidentical-peripheral blood stem cell transplantation for a patient with severe aplastic anemia who developed disseminated fungal infection following immunosuppressive therapy
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  • Hirotoshi Sakaguchi,
  • Norihito Ikenobe,
  • Kentaro Fujimori,
  • Yoshihiro Gocho,
  • Shota Myojin,
  • Masaki Yamada,
  • Ken-Ichi Imadome,
  • Mikiko Miyasaka,
  • Osamu Miyazaki,
  • Akihiro Yoneda,
  • Shotaro Matsumoto,
  • Satoshi Nakagawa,
  • Takao Deguchi,
  • Akihiro Iguchi ,
  • Daisuke Tomizawa,
  • Chikara Ogimi,
  • Kimikazu Matsumoto
Hirotoshi Sakaguchi
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo

Corresponding Author:[email protected]

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Norihito Ikenobe
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Kentaro Fujimori
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Yoshihiro Gocho
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Shota Myojin
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Masaki Yamada
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Ken-Ichi Imadome
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Mikiko Miyasaka
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Osamu Miyazaki
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Akihiro Yoneda
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Shotaro Matsumoto
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Satoshi Nakagawa
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Takao Deguchi
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Akihiro Iguchi
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Daisuke Tomizawa
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Chikara Ogimi
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Kimikazu Matsumoto
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Kenkyujo
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Abstract

Urgent haploidentical hematopoietic cell transplantation may be considered in cases of severe aplastic anemia (SAA) without human leukocyte antigen-matched donor and suffering from severe infection. However, deciding on allogeneic transplantation in the setting of active systemic infection is challenging due to poor outcomes. This report presents a case of disseminated Magnusiomyces capitatus infection in a 5-year-old male who underwent immunosuppressive therapy for hepatitis-associated SAA. To address the critical situation, granulocyte transfusion was promptly administered from the patient’s mother, followed by unmanipulated haploidentical peripheral blood stem cell transplantation from the patient’s father with posttransplant cyclophosphamide, ultimately resulting in successful rescue.