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Outside In: Roles of Complement in Autophagy
  • +1
  • Ben King,
  • Klaudia Kulak,
  • Lucie Colineau,
  • Anna Blom
Ben King
Lund University
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Klaudia Kulak
Lund University
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Lucie Colineau
Lund University
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Anna Blom
Lund University
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Abstract

The complement system is a well-characterised cascade of extracellular serum proteins that is activated by pathogens and unwanted waste material. Products of activated complement signal to host cells via cell-surface receptors, illicting responses such as removal of the stimulus by phagocytosis. The complement system therefore functions as a warning system, resulting in removal of unwanted material. This review describes how extracellular activation of the complement system can also trigger autophagic responses within cells, upregulating protective homeostatic autophagy in response to perceived stress, but also intiating targeted anti-microbial autophagy in order to kill intracellular cyto-invasive pathogens. In particular, we will focus on recent discoveries that complement may also have roles in detection and autophagy-mediated disposal of unwanted materials within the intracellular environment. We therefore summarize the current evidence for complement involvement in autophagy, both by transducing signals across the cell membrane, as well as roles within the cellular environment.

Peer review status:ACCEPTED

14 Apr 2020Submitted to British Journal of Pharmacology
15 Apr 2020Submission Checks Completed
15 Apr 2020Assigned to Editor
17 Apr 2020Reviewer(s) Assigned
20 May 2020Editorial Decision: Revise Minor
15 Jun 20201st Revision Received
18 Jun 2020Submission Checks Completed
18 Jun 2020Assigned to Editor
23 Jun 2020Review(s) Completed, Editorial Evaluation Pending
24 Jun 2020Editorial Decision: Accept