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Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis
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  • Yijie Gao,
  • Lei Ye,
  • Jia-shuo Zhang,
  • Yang-xue Yin,
  • Min Liu,
  • Hong-biao Yu,
  • Rong Zhou
Jia-shuo Zhang
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Yang-xue Yin
Sichuan University West China Second University Hospital
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Min Liu
Sichuan University West China Second University Hospital
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Hong-biao Yu
Sichuan University West China Second University Hospital
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Rong Zhou
Sichuan University West China Second University Hospital
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Abstract

Background: COVID-19 outbreak in Wuhan, China recently. It quickly spread throughout. Objectives: To investigate clinical features and outcomes of pregnant women with COVID-19. Search Strategy: PubMed、Web of Science、EMBASE、MEDLINE were searched from January 1, 2020 to April 16, 2020. Selection Criteria: Case review of pregnant women infected with COVID-19 Data Collection and Analysis: Two reviewers screened 366 literatures and 14 studies included, four reviewers independently extracted the features of the literatures. We used random-effects model to analyze incidence (P) and 95% confidence interval (95%CI). Heterogeneity was assessed using the I2 statistic. Main Results: The meta- analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95%CI, 0.49~0.93), cesarean section (65%; 95%CI, 0.42~0.87), fever (51%; 95%CI, 0.35~0.67), lymphopenia (49%; 95%CI, 0.29~0.70), coexisting disorders (33%; 95%CI, 0.21~0.44), cough (31%; 95%CI, 0.23~0.39), fetal distress (29%; 95%CI, 0.08~0.49), preterm labor (23%; 95%CI, 0.14~0.32), severe case or death (12%; 95%CI, 0.03~0.20). The subgroup analysis showed compared with nonpregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever (pregnant women group, 51%; nonpregnant patients group, 91%; P<0.00001) and cough (pregnant women group, 31%; nonpregnant patients group, 67%; P<0.0001). Conclusions: The incidence of fever, cough and positive CT findings in pregnant women with COVID-19 is less than that in the general population, preterm labor is the opposite. There is no evidence that COVID-19 can propagate vertically for the time being. Keywords: 2019-nCoV, COVID-19, clinical features, pregnancy outcomes, pregnant women, meta-analysis