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Genome analysis of Getah virus (GETV) isolated from and contaminated in a live swine vaccine: The commercial live vaccines might be a potential route for GETV transmission
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  • Feng Zhou,
  • Aojie Wang,
  • Lu Chen,
  • Xingang Wang,
  • Dandan Cui,
  • Hongtao Chang,
  • chuan-qing WANG
Feng Zhou
Henan Agricultural University
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Aojie Wang
Henan Agricultural University
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Lu Chen
Henan Agricultural University
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Xingang Wang
Henan Agricultural University
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Dandan Cui
Henan Agricultural University
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Hongtao Chang
Henan Agricultural University
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chuan-qing WANG
Henan Aricultural University
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Abstract

GETV cause fetus death and reproductive disorders in pigs. In this study, a GETV strain, named GETV-V1, was isolated from a commercial modified live vaccine (MLV) against porcine reproductive and respiratory syndrome virus (PRRSV), which is widely used on pigs in China. Further results showed that nine batches of MLV vaccine (three batches per year) from the same manufacturer between 2015 and 2017 were all positive for GETV. We then further characterized the GETV-V1 strain and performed phylogenetic analysis, revealing that the GETV strains circulating in China are genetically diverse and providing a potential platform for evolution. Therefore, this research firstly reported the contamination of GETV in live attenuated PRRS vaccines in China, implying that monitoring of exogenous virus in live vaccines for pigs needs to be improved.