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The effects of astaxanthin supplementation on the expression of miR-146a and miR-126, oxidative stress and inflammation in patients with type 2 diabetes mellitus: A randomized double blind placebo controlled clinical trial
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  • Amirhossein farokhzad,
  • Nafiseh Sokri Mashhadi,
  • Maryam Tahmasebi,
  • Javad Mohammadi-asl,
  • Mehrnoosh Zakerkish,
  • Majid Mohammadshahi
Amirhossein farokhzad
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Nafiseh Sokri Mashhadi
Isfahan University of Medical Sciences
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Maryam Tahmasebi
Ahvaz Jondishapour University of Medical Sciences
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Javad Mohammadi-asl
Ahvaz Jondishapour University of Medical Sciences
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Mehrnoosh Zakerkish
Ahvaz Jondishapour University of Medical Sciences
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Majid Mohammadshahi
Ahvaz Jondishapour University of Medical Sciences
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Abstract

Background: The pathogenesis of type 2 diabetes (T2D) is associated with chronic oxidative stress and inflammation. It is well known that the expression of some miRNAs such as miRNA-146a up- regulate in diabetic and hyperglycemic patients whereas, circulating miRNA-126 reduces. Therefore, the purpose of this study was to determinate the effects of Astaxanthin supplementation on the expression of miR-146a and miR-126, MDA and inflammation in patients with type 2 diabetes. Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 44 type 2 diabetes patients who were randomly assigned to received 8mg of oral Astaxanthin/d (n=22) or placebo(n=22) for 8 weeks. Results: We observed that Astaxanthin supplementation could decrease plasma levels of MDA and IL-6 (P < 0.05) and declined the expression level of miR-146a over time (Fold change: -1/388) (P < 0.05). Conclusion: Astaxanthin supplementation might be beneļ¬cial for improving circulating MDA and IL-6 and down regulation of miR-146a. However, future investigations are suggested to confirm these results.

Peer review status:UNDER REVIEW

07 Sep 2020Submitted to International Journal of Clinical Practice
15 Sep 2020Assigned to Editor
15 Sep 2020Submission Checks Completed
16 Sep 2020Reviewer(s) Assigned