loading page

Successful treatment of 5-fluorouracil mediated cardiotoxicity with uridine triacetate in a pediatric patient
  • +2
  • Gisela Marrero-Rivera,
  • Cori Morrison,
  • Zachary LeBlanc,
  • Maria Velez,
  • Dana Leblanc
Gisela Marrero-Rivera
Louisiana State University in New Orleans
Author Profile
Cori Morrison
Louisiana State University Health Sciences Center
Author Profile
Zachary LeBlanc
Louisiana State University Health Sciences Center
Author Profile
Maria Velez
Louisiana State University Health Sciences Center
Author Profile
Dana Leblanc
Louisiana State University Health Sciences Center
Author Profile

Abstract

5-fluorouracil (5-FU) is a pyrimidine analogue used to treat adults with a variety of carcinomas but less frequently used in pediatrics. 5-FU is a well-recognized cardiotoxic chemotherapy medications, particularly among adults with underlying cardiovascular disease, however this has rarely been reported in the pediatric population. We report a rare case of 5-FU induced cardiomyopathy in a pediatric patient with nasopharyngeal carcinoma (NPC), successfully managed with milrinone and uridine triacetate, underscoring the need for awareness and prompt recognition and medication administration for this potentially reversible condition.