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RESPIRATORY OUTCOMES OF “NEW” BRONCHOPULMONARY DYSPLASIA IN ADOLESCENTS: A MULTICENTER STUDY
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  • Santiago Perez-Tarazona,
  • Santiago Rueda Esteban,
  • Maria Luz García-García,
  • Maria Arroyas Sanchez,
  • Ines de Mir Messa,
  • Tatiana Acevedo Valarezo,
  • Orlando Mesa Medina,
  • Alicia Callejón,
  • Elisa Canino Calderín,
  • Salomé Albi Rodriguez,
  • Roser Ayats Vidal,
  • Antonio Salcedo Posadas,
  • Jordi Costa-Colomer,
  • Xavier Domingo Miró,
  • Montserrat Berrocal Castañeda,
  • Ana Villares
Santiago Perez-Tarazona
La Fe University and Polytechnic Hospital
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Santiago Rueda Esteban
San Carlos University Hospital
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Maria Luz García-García
Severo Ochoa University Hospital
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Maria Arroyas Sanchez
Severo Ochoa University Hospital
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Ines de Mir Messa
Vall d'Hebron Hospital Universitari
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Tatiana Acevedo Valarezo
Vall d’Hebron Hospital Universitari
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Orlando Mesa Medina
Nuestra Senora de la Candelaria University Hospital
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Alicia Callejón
Nuestra Senora de la Candelaria University Hospital
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Elisa Canino Calderín
Hospital Universitario Materno Infantil de Canarias
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Salomé Albi Rodriguez
Hospital Universitario 12 de Octubre
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Roser Ayats Vidal
Corporate Healthcare Consortium Parc Taulí
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Antonio Salcedo Posadas
General University hospital Gregorio Maranon
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Jordi Costa-Colomer
Hospital Sant Joan de Deu
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Xavier Domingo Miró
Corporate Healthcare Consortium Parc Taulí
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Montserrat Berrocal Castañeda
Complexo Hospitalario de Ourense
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Ana Villares
Complexo Hospitalario de Ourense
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Abstract

Objective Long-term respiratory consequences of bronchopulmonary dysplasia (BPD) in preterm infants born in the post-surfactant era (“new” BPD) remain partially unknown. The present study aimed to evaluate respiratory outcomes of “new” BPD in adolescents who were born preterm. Methods This multicenter, cross-sectional study included 286 adolescents born between 2003 and 2005 (mean age: 14.2 years); among them, 184 and 102 were born extremely preterm (EP) (< 28 weeks’ gestation) and moderate-late preterm (32 to < 37 weeks’ gestation), respectively. Among EP adolescents, 92 had BPD, and 92 did not. All participants underwent lung function tests, skin prick testing, and questionnaires on asthma symptoms and quality of life. Results EP adolescents with BPD had significantly lower forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow between 25%–75% of FVC than other included adolescents. FEV1/FVC ratios were below the lower limit of normal (z-score < −1.645) in 30.4% of EP adolescents with BPD, 13.0% of EP adolescents without BPD, and 11.8% of adolescents who were born moderate-late preterm. Bronchodilator response and air-trapping were significantly higher in BPD adolescents than in other adolescents. Diffusion capacity was significantly lower in EP adolescents than in moderate-late preterm adolescents. Asthma symptoms and quality of life scores were similar among groups. Conclusion EP adolescents with “new” BPD had poorer pulmonary function than EP adolescents without BPD or moderate-late preterm adolescents. Further studies are needed to determine whether “new” BPD is associated with early-onset chronic obstructive pulmonary disease in adulthood.

Peer review status:ACCEPTED

28 Sep 2020Submitted to Pediatric Pulmonology
29 Sep 2020Submission Checks Completed
29 Sep 2020Assigned to Editor
01 Oct 2020Reviewer(s) Assigned
13 Oct 2020Review(s) Completed, Editorial Evaluation Pending
17 Oct 2020Editorial Decision: Revise Minor
06 Nov 20201st Revision Received
10 Nov 2020Submission Checks Completed
10 Nov 2020Assigned to Editor
10 Nov 2020Reviewer(s) Assigned
25 Nov 2020Review(s) Completed, Editorial Evaluation Pending
25 Nov 2020Editorial Decision: Revise Minor
03 Dec 20202nd Revision Received
04 Dec 2020Submission Checks Completed
04 Dec 2020Assigned to Editor
04 Dec 2020Reviewer(s) Assigned
08 Dec 2020Review(s) Completed, Editorial Evaluation Pending
10 Dec 2020Editorial Decision: Accept