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The Ingenious Mast Cell: Contemporary insights into mast cell behavior and function
  • +3
  • Joakim Dahlin,
  • Marcus Maurer,
  • Dean Metcalfe,
  • Gunnar Pejler,
  • Ronit Sagi-Eisenberg,
  • Gunnar Nilsson
Joakim Dahlin
Karolinska Institutet
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Marcus Maurer
Charité Universitätsmedizin Berlin
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Dean Metcalfe
NIAID
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Gunnar Pejler
Uppsala Universitet
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Ronit Sagi-Eisenberg
Tel Aviv University Sackler Faculty of Medicine
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Gunnar Nilsson
Karolinska Institutet
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Abstract

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells and epithelial cells. During recent years, clinical and experimental studies on human mast cells as well as experiments using animal models have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity and reactivity. We also highlight the development in our understanding of mast cell driven-diseases and discuss the development of novel strategies to treat such conditions.

Peer review status:Published

27 Oct 2020Submitted to Allergy
28 Oct 2020Submission Checks Completed
28 Oct 2020Assigned to Editor
30 Oct 2020Reviewer(s) Assigned
22 Nov 2020Review(s) Completed, Editorial Evaluation Pending
23 Nov 2020Editorial Decision: Revise Minor
16 Mar 20211st Revision Received
17 Mar 2021Submission Checks Completed
17 Mar 2021Assigned to Editor
17 Mar 2021Reviewer(s) Assigned
12 Apr 2021Review(s) Completed, Editorial Evaluation Pending
15 Apr 20212nd Revision Received
16 Apr 2021Submission Checks Completed
16 Apr 2021Assigned to Editor
16 Apr 2021Review(s) Completed, Editorial Evaluation Pending
16 Apr 2021Editorial Decision: Accept
06 May 2021Published in Allergy. 10.1111/all.14881