Background Pediatric patients with oncologic and hematologic diagnoses who experience functional decline during a hospitalization may benefit from intensive therapies. However, acute medical issues or disease treatment plans may prevent a safe transfer to the inpatient rehabilitation unit. Accordingly, an alternative inpatient rehabilitation program was developed. Procedure Short-term Pediatric Rehabilitation Intensive Therapy (“SPRINT”) is a 2-week inpatient intensive therapy program developed for pediatric patients on hematology-oncology and bone marrow transplant units at a pediatric tertiary care hospital. This pilot study evaluates functional outcomes of SPRINT participants measured by the Caregiver Assistance section of the Pediatric Evaluation of Disability Inventory (PEDI) and differences in participants’ symptoms with a questionnaire. Results Eighteen pediatric patients (50% female, age 1.9-17.8 years) participated in SPRINT, and 11 parents and 4 children completed questionnaires. Common diagnoses included leukemia and lymphoma (N=9, 50%) and central nervous system tumor (N=6, 33%). Deconditioning (N=18, 100%) and peripheral neuropathy (N=8, 44.4%) were common rehabilitation diagnoses. Significant gains were found in tasks in self-care and mobility domains of PEDI (all p<0.05), as well as functional expression in social function domain (p=0.03). No adverse events related to SPRINT participation were identified. There was no significant difference between pre- and post-SPRINT questionnaire responses. Conclusion SPRINT is an alternative model for intensive rehabilitation care delivery. Data suggest that SPRINT participation can result in significant functional gains in mobility, self-care, and functional expression for pediatric patients with hematologic and oncologic diagnoses during hospitalizations. No difference was found in questionnaire responses after SPRINT participation.