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An unusual case of Chronic Lymphocytic Leukemia with trisomy 12 presenting with prolymphocytic transformation and new translocation 8;21.
  • Mishi Bhushan,
  • Kirthi Kumar
Mishi Bhushan
Medical City Dallas Hospital
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Kirthi Kumar
Medical City Dallas Hospital
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Abstract

Patient with a long history of CLL and known trisomy 12 presented with rapidly rising lymphocytosis, bulky adenopathy, and splenomegaly. Peripheral blood and bone marrow exam showed preponderance of prolymphocytes. Cytogenetic analysis showed an abnormal male karyotype with trisomy 12 and a new t(8;21) translocation in the same 6 metaphases.

Peer review status:ACCEPTED

06 Nov 2020Submitted to Clinical Case Reports
26 Nov 2020Submission Checks Completed
26 Nov 2020Assigned to Editor
08 Dec 2020Reviewer(s) Assigned
13 Dec 2020Review(s) Completed, Editorial Evaluation Pending
15 Dec 2020Editorial Decision: Revise Minor
20 Feb 20211st Revision Received
23 Feb 2021Submission Checks Completed
23 Feb 2021Assigned to Editor
23 Feb 2021Review(s) Completed, Editorial Evaluation Pending
03 Mar 2021Editorial Decision: Accept