chylothorax is a relatively uncommon condition. It is characterized by the presence of chylous rich fluid within the pleural space. Spontaneous chylothorax usually refers to non-traumatic causes most common malignancy and infections. we present a case of a spontaneous chylothorax with evidence of resolution of pleural effusion without detectable cause.
Thrombocytosis is common in children with sickle cell disease (SCD). Reactive thrombocytosis must be distinguished from myeloproliferative disorder or inherited thrombocytosis syndrome. We present an adolescent with hemoglobin SS and thrombocytosis associated with increased frequency of pain, priapism, and acquired von Willebrand disease.
A fetus harboring a duplication of SMAD2 exons 1-6 presented with dextrocardia and pulmonary hypoplasia. Mate-pair sequencing revealed the duplication to be in inverted tandem orientation to the wild-type SMAD2 allele, disrupting its sequence and decreasing expression. These observations suggest SMAD2 to be responsible for the fetal dextrocardia.
Mucinous cystic neoplasm of the liver is a rare slow-growing lesion accounting for less than 5% of all hepatic cystic neoplasms. Differential diagnosis from other cystic lesions remains challenging despite progress achieved in the radiological modalities. Only histopathological examination of the surgical specimen establishes with certainty the diagnosis.
We found no significant differences in platelet function in patients with severe HA in prophylactic treatment before and after FVIII infusion. After FVIII administration, patients presented fewer endothelial microvesicles, indicating that the treatment does not increase one of the possible thrombotic risk markers of these patients.
COVID-19 related pneumonia overlaps with ACS, one of the most common acute presentations in SCD patients.We present a case of 22-year-old SCD patient presented to the emergency department with mild respiratory symptoms turned out to be COVID-19 positive and received red blood cell exchange to avoid the possibility of deterioration.
Hand and foot syndrome (HFS) is a toxic dermatologic reaction to chemotherapy, commonly described with capecitabine, 5fluouracile, vinorelbine, and cytarabine. Taxanes are less likely to induce HFS, and very few cases reported paclitaxel-induced HFS. We report a serious case of HFS induced by paclitaxel in a breast cancer female.
1.7% of myeloproliferative neoplasms are associated with autoimmune conditions. Association of myasthenia gravis (MG) with chronic myeloid leukemia is reported, but its association with polycythemia vera (PV) has never been reported. We report two patients who had MG and PV with JAK2V617F mutation. Both had splenomegaly but no thymoma.
Serum sickness, a reaction presenting with a classic triad (fever, rash, myalgia/arthralgia) and considered as a rare adverse event following monoclonal antibodies and specifically following treatment with rituximab. This report describes a case of serum sickness in a newly treated young male patient with rituximab for pemphigus vulgaris.
Lockdown measures because of COVID-19 pandemic have had a major impact on patients’ mental health. We present the case of an 80-year-old patient, reactivating World War Two memories during lockdown period. We looked for posttraumatic stress disorder (PTSD). She also presented with a rheumatoid arthritis flare after disease control
Herein we report a case of a ten years old boy with rare clinical manifestations associated with COVID-19, in which the first clinical symptoms were urticaria and fever, and then he developed arthritis. The possibility of post-COVID-19, reactive arthritis, or postinfectious arthritis can be expected from this virus.
There is evidence of increased incidence, rapid progression, and poor prognosis of Covid-19 in patients with underlying comorbidities such as diabetes and epilepsy. It is crucial to develop effective treatment regimens for these patients. Multiple organ failure is the most common cause of death in Covid-19 patients.
we reported an18 years old male with beta thalassemia major who presented with back pain progressive over 1 month associated with numbness in thighs, together with lower limbs weakness and difficulty walking. he also mentioned having difficulty in passing urine. he received radiotherapy which results in significant improvement in symptoms
Euglycemic DKA (euDKA) is a serious side effect associated with SGLT2 inhibitors. We present a case euDKA in a patient on an SGLT-2 inhibitor likely precipitated by COVID-19 infection. We suspect that COVID-19 led to euDKA. We pose the question of whether these medications should be discontinued proactively.