loading page

Clinical Research out of Insulin Glargine U300 basal bolus therapy and Insulin Degludec/Aspart Co-Formulation in Type 2 Diabetes Mellitus: A Real World Experience
  • +7
  • savas volkan Kisioglu,
  • Ahmet Suat Demir,
  • damla tufekci,
  • Yasemin Emur Gunay,
  • Hulya Coskun,
  • Ozge Ucuncu,
  • Irfan Nuhoglu,
  • Mustafa Kocak,
  • Serdar Karakullukcu,
  • Halil Onder ERSOZ
savas volkan Kisioglu
Trabzon Training and Research Hospital
Author Profile
Ahmet Suat Demir
Author Profile
damla tufekci
Author Profile
Yasemin Emur Gunay
Author Profile
Hulya Coskun
Author Profile
Ozge Ucuncu
Author Profile
Irfan Nuhoglu
Author Profile
Mustafa Kocak
Author Profile
Serdar Karakullukcu
Author Profile
Halil Onder ERSOZ
Author Profile

Abstract

Aims/Introduction: Insulin Degludec/Aspart (IDegAsp) and Insulin Glargine U300 (IGlarU300) have recently emerged as popular new-generation insulin analogs. The aim of this real-life study was to investigate the patient profiles in which IGlarU300 and IDegAsp were preferred and the insulin combinations after which each of them were mostly used, and also to analyze the effect of these two insulin analogs on blood glucose regulation and hypoglycemia. Materials and Methods: The retrospective study included 174 patients that were switched from basal insulin, basal+bolus insulin, or premixed insulin to IGlarU300 or IDegAsp due to uncontrolled blood glucose levels or history of hypoglycemia. Hypoglycemia, body weight, body mass index (BMI), fasting blood glucose (FBG), and HbA1c levels over three-month periods were evaluated for each patient. Results: There were 84 and 90 patients in the IGlarU300 and IDegAsp groups, respectively. Body weight was similar in both groups. Baseline FBG and HbA1c levels in the IGlarU300 and IDegAsp groups were 9.0%, 175.5 mg/dl and 9.4%, 193.5 mg/dl, respectively. A significant decrease was found in FBG and HbA1c levels in both groups (138.5, 7.8 vs. 141.5, 8.2; p<0.001 for all). Moreover, a significant weight gain was observed in both groups (p<0.05 for both). The prevalence of hypoglycemia in both groups decreased significantly and consistently between month 1 and 9 (p<0.001). At month 12, although this decrease continued in the IGlarU300 group (p=0.013), no significant decrease was observed in the IDegAsp group(p=0.057). Conclusion: Both twice-daily IDegAsp┬▒bolus insulin and IGlarU300+bolus insulin therapies are effective and safe treatment modalities.

Peer review status:ACCEPTED

04 Jan 2021Submitted to International Journal of Clinical Practice
05 Jan 2021Submission Checks Completed
05 Jan 2021Assigned to Editor
09 Jan 2021Reviewer(s) Assigned
01 May 2021Review(s) Completed, Editorial Evaluation Pending
02 May 20211st Revision Received
06 May 2021Submission Checks Completed
06 May 2021Assigned to Editor
06 May 2021Review(s) Completed, Editorial Evaluation Pending
08 May 2021Reviewer(s) Assigned
11 May 2021Editorial Decision: Accept