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Group B Streptococcus Colonisation, Prevalence, Associated Risk Factors and Antimicrobial Susceptibility Pattern Among Pregnant Women Attending Antenatal Care at Dschang District Hospital, West Region of Cameroun: A hospital-based Cross Sectional Study
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  • Leonard Sama,
  • michel Noubom,
  • Christelle KENNE ,
  • Thibau Tchouangueu,
  • omer Ngouateu,
  • Albert Atsamoh,
  • osein karimo,
  • christopher tume
Leonard Sama
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michel Noubom
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Christelle KENNE
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Thibau Tchouangueu
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omer Ngouateu
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Albert Atsamoh
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osein karimo
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christopher tume
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Abstract

Background: Group B streptococcus (GBS), also name as Streptococcus agalactiae, is a gram-positive bacterium know for it capacity to colonises the vaginal and rectal areas of the mother and is a leading cause of neonatal mortality and morbidity. This study aimed at determining the prevalence, associated risk factors and antimicrobial susceptibility of GBS colonization among pregnant women attending antenatal care at Dschang District Hospital. Methods: This hospital-base cross-sectional study targeted pregnant women population attending hospitals for routine prenatal testing using a multistage sampling method. Pregnant women at 23.46 ± 6.44 weeks gestation completed a questionnaire and vaginal swabs were obtained for GBS analysis. Data were analysed using chi-squared (χ2) test or the Fisher’s exact test when appropriate and the multivariable logistic regression models. Results: The colonisation rate of GBS among pregnant women was 8.69%. Induce abortion (odds ratio [CI] = 3.09, 95% [1.56-6.21]), Spontaneaous abortions (OR= 2.82, 95% CI 1.14-7.29), Stillborn (OR [CI] = 7.75, 95% [2.61-21.71]), Fever (OR [CI] = 0.37, 95% [0.19-0.71]) and anemia (OR [CI] = 0.22, 95% [0.12-0.43]) were found to be influencing factors associated with GBS colonisation. Conclusion: Our findings suggest that none of the studied factors were significantly associated with GBS colonisation. Further longitudinal research is needed to establish the causal relationship and its biological mechanisms. Keys words: Group B Streptococcus, Prevalence, Risk Factors, Antimicrobial Susceptibility, Pregnant Women

Peer review status:IN REVISION

04 Feb 2021Submitted to International Journal of Clinical Practice
05 Feb 2021Assigned to Editor
05 Feb 2021Submission Checks Completed
18 Feb 2021Reviewer(s) Assigned
16 May 2021Review(s) Completed, Editorial Evaluation Pending
19 Jun 20211st Revision Received