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Microwave ablation as an efficient therapy for primary hyperparathyroidism: Efficacy and predictors of treatment success
  • +1
  • Mehmet Sercan Ertürk,
  • Bulent Cekic,
  • Isilay Sarı,
  • Baris Pamuk
Mehmet Sercan Ertürk
Izmir Katip Celebi University School of Medicine, Ataturk Education and Research Hospital
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Bulent Cekic
University of Health Sciences Antalya Training and Research Hospital, Department of Radyology, 07010, Antalya, Turkey
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Isilay Sarı
University of Health Sciences Antalya Training and Research Hospital
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Baris Pamuk
Izmir Katip Celebi University, School of Medicine
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Abstract

Background:Microwave ablation has a great potential to treat primary hyperparathyroidism; but its predictors and the therapeutic efficiency are not clear enough and so the more investigations are required. Aim:The purpose of this study was to explore safety and predictors of the MWA efficacy in patients with primary hyperparathyroidism (PHPT) induced by parathyroid adenoma. Methods: Patients with PHPT treated with MWA were included in this study. Depending on the treatment efficacy, patients divided into two groups as response and no response group. Possible predictors as age, gender, Parathyroid adenoma volume, baseline levels of calcium (Ca), phosphorous (P), alkaline phosphate (ALP), vitamin D and location of parathyroid adenoma and the instrumental parameters which are microwave ablation time and power were compared between two groups. The resulting possible predictors the MWA efficacy exhibiting statistically significant difference was investigated by using logistic regression. Results: Thirty-two patients participated into predictor analysis for MWA efficacy. Comparison of the values of response and no response groups in terms possible predictors revealed only the baseline Ca level as the potential predictor of the efficacy of MWA (P <0.05). Further logistic regression results showed the baseline Ca level as insignificant to construct a mathematical model to predict the efficacy of MWA (P = 0.071). Furthermore, a significant difference in time differences was observed after 1 day of the MWA treatments in the levels of Ca, P, and PHT except than ALP, those of which was 30 days later (P <0.001). Later on, the difference stayed steady until the end of follow up. Conclusions:MWA is an effective and safe therapy for in patients with PHPT caused by parathyroid adenoma. Baseline Ca level has been found as potential but detailed investigations revealed none of the explored factors as predictive for the assessed patients. Keywords:Primary hyperparathyroidism, microwave ablation, predictor, efficacy

Peer review status:UNDER REVIEW

03 Mar 2021Submitted to International Journal of Clinical Practice
03 Mar 2021Submission Checks Completed
03 Mar 2021Assigned to Editor
07 Mar 2021Reviewer(s) Assigned
19 Mar 2021Review(s) Completed, Editorial Evaluation Pending
03 Apr 20211st Revision Received
04 Apr 2021Assigned to Editor
04 Apr 2021Submission Checks Completed
08 Apr 2021Reviewer(s) Assigned
05 May 2021Review(s) Completed, Editorial Evaluation Pending
29 May 20212nd Revision Received
01 Jun 2021Assigned to Editor
01 Jun 2021Review(s) Completed, Editorial Evaluation Pending
01 Jun 2021Submission Checks Completed
05 Jun 2021Reviewer(s) Assigned