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Insights in animal models for translational cardiovascular research:A pharmaceutical industry perspective
  • +4
  • ziyin wu,
  • Liang Cao,
  • Zeyu Cao,
  • Tuanjie Wang,
  • Zhenzhong Wang,
  • Xin Wang,
  • Wei Xiao
ziyin wu
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process
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Liang Cao
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process
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Zeyu Cao
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process
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Tuanjie Wang
Jiangsu Kanion Pharmaceutical Co.,Ltd.
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Zhenzhong Wang
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process
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Xin Wang
The University of Manchester
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Wei Xiao
Jiangsu Kanion Pharmaceutical Co.,Ltd.
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Abstract

The pathological mechanisms involved in Heart failure (HF) are complex and remain controversial. Caused by a variety of predisposing and exacerbating factors for HF development, the selection of animal models in current preclinical R&D has been a major challenge. In this review, we give a comprehensive overview of different models in various species currently used in HF research, and discuss their general applicability. In addition, we summarize the preclinical research review of approved drugs for HF, which provides theoretical and practical guidance for researchers considering preclinical studies for the treatment of HF.