Introduction: Due to the high mortality of coronavirus disease 2019 (COVID-19), There are difficulties in the management of the emergency department. As such, we investigated whether the d-dimer/albumin ratio (DAR) and fibrinogen/albumin ratio (FAR) predicts mortality in the COVID-19 patients. Methods: A total of 717 COVID-19 patients who were brought to the emergency department within the period from March to October 2020 were included in the study. The d-dimer level, fibrinogen level, albumin level, DAR, FAR, age, gender, and in-hospital mortality status of the patients were recorded. The patients were grouped by in-hospital mortality. Statistical comparison was conducted between the groups. Results: Of the patients who were included in the study, 371(51.7%) were male, and their median age was 64 years (50–74). There was in-hospital mortality in 126 (17.6%) patients. The area-under-the-curve (AUC) and odds ratio values obtained by DAR to predict in-hospital mortality were higher than the values obtained by the all other parameters (AUC of DAR, albumin, d-dimer, FAR, and fibrinogen: 0.773, 0.766, 0.757, 0.703, and 0.637, respectively; odds ratio of DAR>56.36, albumin<4.015, d-dimer>292.5, FAR>112.33, and fibrinogen>423: 7.898, 6.216, 6.058, 4.437, and 2.794, respectively). In addition; patients with concurrent DAR>56.36 and FAR>112.33 had an odds ratio of 21.879 referring to patients with concurrent DAR<56.36 and FAR<112.33. Conclusion: DAR was found to be more valuable than the other parameters. In addition the concurrent high levels of DAR and FAR levels were found to be more valuable in predicting in-hospital mortality compared to a separate evaluation. Keywords: Covid-19, D-dimer, Fibrinogen, Serum Albumin, in-Hospital Mortality