Objective: This study aimed to assess the impact of clinical pharmacist services addition to cardiac rehabilitation program, on high sensitivity C-reactive protein and echocardiographic parameters. Methods: The study was a prospective; randomized, controlled study. A total of 40 post-acute coronary syndrome (ACS) patients participating in cardiac rehabilitation program were randomly allocated to either the control group (n = 20) or the clinical pharmacist-provided services group (n = 20). High sensitivity C-reactive protein (hs-CRP) and echocardiographic parameters (left ventricular end systolic volume (LVESV), left ventricular end systolic volume (LVEDV) and ejection fraction (EF%) were compared between both groups at baseline and after 3 months. Results: After three months of follow-up, the intervention group showed a significant decrease in the percent change of hsCRP, LVESV and LVEDV compared to the control group. However, there was no statistical difference in the percent change of ejection fraction between both groups. Conclusion: Addition of clinical pharmacist services to cardiac rehabilitation program had resulted in marked decrease in hs-CRP, LVESV and LVEDV. Understanding the impact of the clinical pharmacist-provided services in post-ACS patients may encourage clinical implementation of this model in cardiac rehabilitation programs.