Anti-adhesion surfaces capable of repelling various liquids would have broad technological implications. However, the on-site application of such surfaces has been limited by the need for complex processes and extra equipment. Here we have created a solvent-free mixture containing miscible silicon precursors, which can be readily sprayed, dipped, or painted onto virtually any substrate to prepare flat anti-adhesion coatings. By embedding the lubricating silicon segments on surfaces via the novel synergetic reactions that spontaneously occur at room temperature, we can fabricate coatings that are readily applicable on-site to cover large objects, and which offer excellent repellency against various liquids (water, hydrocarbons, crude oil, and oily-ink) as well as viscoelastic and sticky adhesives. These coatings are transparent, flexible, and durable. We believe these coatings can be utilized in many commercial and residential situations to address a wide range of undesirable interfacial adhesion issues such as smudge, drag, and blockage.