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Phomopsidione loaded chitosan polyethylene glycol (PEG) nanocomposite dressing for pressure ulcers
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  • Ihsan Idris Chin,
  • Woei Yenn Tong,
  • Chean Ring Leong,
  • Yusriah Lazim,
  • Wen-Nee Tan,
  • Syarifah Ab Rashid,
  • See Yuan Cheng,
  • Zaida Rahayu Yet,
  • Siti Zubaidah Abdullah,
  • Md Taher
Ihsan Idris Chin
University of Kuala Lumpur
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Woei Yenn Tong
University of Kuala Lumpur
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Chean Ring Leong
University of Kuala Lumpur
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Yusriah Lazim
University of Kuala Lumpur
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Wen-Nee Tan
Universiti Sains Malaysia
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Syarifah Ab Rashid
University of Kuala Lumpur
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See Yuan Cheng
Universiti Teknikal Malaysia - Main Campus
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Zaida Rahayu Yet
University of Kuala Lumpur
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Siti Zubaidah Abdullah
University of Kuala Lumpur
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Md Taher
Universiti Kuala Lumpur
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Peer review status:POSTED

09 Apr 2020Submitted to Biotechnology and Bioengineering
10 Apr 2020Assigned to Editor
10 Apr 2020Submission Checks Completed

Abstract

Pressure ulcers are commonly associated with microbial infections on the wounds which need an effective wound dressing. However, the silver dressings have shown promising result but they have toxicity and argyria. Hence, this study aimed to develop and characterize chitosan-polyethylene glycol (PEG) nanocomposite hydrogel loaded with phomopsidione as an antimicrobial dressing. The hydrogel being synthesized was analyzed with transmission and scanning electron microscopes. Drug release and mechanical properties were studied having confirmed the functional groups with Fourier transform infrared (FTIR) spectroscopy. Finally, antimicrobial activities were evaluated against the clinical wound pathogens. The developed hydrogel was soft, flexible and elastic, having nanospheres of chitosan-PEG but no sign of aggregation under the electron microscopes. Releasing of phomopsidione from the nanocomposite hydrogel was slow and gradual following the first order of kinetic. On average, 34 μg/mL phomopsidione released per hour and 67.9% active ingredients delivered into the surrounding medium over the study period. Although, the bioactivity activity of the hydrogel was narrow-spectrum, it showed significant results against all Gram-negative bacteria and Candida utilis with 99.99% reduction of microbial growth. The findings reveal that the phomopsidione loaded hydrogel has a great promise to act as an antimicrobial dressing for chronic wounds.