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Prognostic Factors for Surgical Margin Status and Recurrence in Partial Nephrectomy
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  • Hüseyin Cihan Demirel,
  • Sedat Çakmak,
  • Abdullah Hızır Yavuzsan,
  • Cumhur Yeşildal,
  • Semih Türk,
  • Ayhan Dalkılıç,
  • Sinan Levent KireççiOrcid,
  • Emre TokuçOrcid,
  • Kaya Horasanlı
Hüseyin Cihan Demirel
Sisli Hamidiye Etfal Training and Research Hospital
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Sedat Çakmak
Sisli Hamidiye Etfal Training and Research Hospital
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Abdullah Hızır Yavuzsan
Sisli Hamidiye Etfal Training and Research Hospital
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Cumhur Yeşildal
Sisli Hamidiye Etfal Training and Research Hospital
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Semih Türk
Sisli Hamidiye Etfal Training and Research Hospital
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Ayhan Dalkılıç
Sisli Hamidiye Etfal Training and Research Hospital
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Sinan Levent Kireççi
Orcid
Sisli Hamidiye Etfal Training and Research Hospital
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Emre Tokuç
Orcid
Sultanbeyli State Hospital
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Kaya Horasanlı
Sisli Hamidiye Etfal Training and Research Hospital
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Peer review status:Published

01 May 2020Submitted to International Journal of Clinical Practice
02 May 2020Submission Checks Completed
02 May 2020Assigned to Editor
04 May 2020Reviewer(s) Assigned
02 Jun 2020Review(s) Completed, Editorial Evaluation Pending
03 Jun 20201st Revision Received
05 Jun 2020Submission Checks Completed
05 Jun 2020Assigned to Editor
05 Jun 2020Reviewer(s) Assigned
08 Jun 2020Review(s) Completed, Editorial Evaluation Pending
12 Jun 2020Editorial Decision: Accept
Published in International Journal of Clinical Practice. 18 Jun 2020. 10.1111/ijcp.13587

Abstract

Purpose: To evaluate the prognostic factors affecting surgical margin and recurrence in patients who underwent partial nephrectomy for renal masses. Materials and Methods: Data of 125 patients who underwent open or laparoscopic partial nephrectomy due to renal mass between January 2006 and January 2019 were analyzed retrospectively. Demographic data, habits, additional diseases, clinical and laboratory findings, operational data, the morphology of the tumor in computerized tomography or magnetic-resonance imaging and follow-up data were scanned and acquired via our hospital’s system and archive. Results: Average age was 54.4, male-female ratio was 1.55 and average tumor size was 3.31 cm. 104 patients had malignant pathology and 21 was benign. Positive surgical margin rate was 5.6% and recurrence rate was 3.2%. Average follow-up was 47.4 months. Pathological size of the tumor was larger (p=0.006), warm-ischemia period was lower (p=0.003), and PADUA score was higher (p=0.015) in open technique. Tumor size and tumor stage were statistically higher in patients with recurrence (p=0.009, p<0.001 respectively). No statistically significant difference was observed between surgical margin positivity and tumor size, Fuhrman grades, PADUA scores, R.E.N.A.L. scores, and C-index. (p>0.05) Conclusion: Surgical margin positivity after partial nephrectomy is not significantly associated with tumor characteristics and anatomical scoring systems. Tumor size and stage after partial nephrectomy are valuable parameters in evaluating the recurrence risk. Keywords: nephrectomy, recurrence, margins of excision, prognosis