Abstract: Background: COVID-19 burst in Wuhan China in December 2019 and soon became a worldwide emergency. To help further understand COVID-19. Here we report the epidemiological, clinical features, potential biomarkers, and CT changes of cases in Wenzhou. Methods:All 64 cases were diagnosed by positive of PCR test. Clinical laboratory tests, CT and treatment were performed in the level 3 of protection. Data and clinical characteristics feature were collected by 4th March. The correlation was analyzed. Results:Most cases were light. The average of latency was 3.4 days, ranged from 1-14. The median age was 44, ranged from 2.2-67; 36 male and 28 female; 59 had fever, 38 with high temperate (>38℃); 45 had respiratory symptoms; 28 had gastrointestinal symptoms; 39 weakness; one asymptomatic case was found. Most with low LC, K+, Na+, OI and high LDH, CRP, D-dimer. Pneumonia, both lungs involvement, ground-glass opacity and consolidation were shown by CTs. Minor had electrocardiography change. Conclusions:The clinical features, abnormality lab indexes and CT characteristics of COVID-19 were like SARS, majored in fever, weakness along with dry cough, diarrhea. LC, LDH could be good biomarkers monitoring progress. The elders, hypertension patients and smokers were more vulnerable. COVID-19 was milder, but more transmissible than SARS. Latency could be up to 14 days without symptoms. CT and PCR shall be both considered in clinical high suspicion. There are still further efforts to be made as to preventing and control the epidemic and the cost in world wild.