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AllergoOncology: Biomarkers and Refined Classification for Research in the Allergy and Glioma Nexus - a Joint EAACI-EANO Position Paper
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  • Michelle Turner,
  • Urszula Radzikowska,
  • Denisa Ferastraoaru,
  • Mariona Pascal,
  • Pieter Wesseling,
  • Alex McCraw,
  • Claudine Backes,
  • Heather Bax,
  • Christoph Bergmann,
  • Rodolfo Bianchini,
  • Luigi Cari,
  • Leticia De las Vecillas,
  • Elena Izquierdo,
  • Frida Lind-Holm Mogensen,
  • Alessandro Michelucci,
  • Petr V. Nazarov,
  • Simone P. Niclou,
  • Giuseppe Nocentini,
  • Markus Ollert,
  • Matthias Preusser,
  • Nataliya Rohr-Udilova,
  • Andrea Scafidi,
  • Reka Toth,
  • Mieke Van Hemelrijck,
  • Michael Weller,
  • Uta Jappe,
  • Maria Escribese,
  • Erika Jensen-Jarolim,
  • Sophia Karagiannis,
  • Aurelie Poli
Michelle Turner
Fundacion Privada Instituto de Salud Global Barcelona
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Urszula Radzikowska
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Denisa Ferastraoaru
Montefiore Medical Center
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Mariona Pascal
Hospital Clinic de Barcelona Centre de Diagnostic Biomedic
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Pieter Wesseling
Amsterdam UMC Locatie VUmc Afdeling Pathologie
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Alex McCraw
King's College London School of Basic & Medical Biosciences
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Claudine Backes
Luxembourg Institute of Health
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Heather Bax
King's College London School of Basic & Medical Biosciences
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Christoph Bergmann
RKM740 Interdisciplinary Clinics
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Rodolfo Bianchini
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Luigi Cari
Universita degli Studi di Perugia Dipartimento di Medicina e Chirurgia
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Leticia De las Vecillas
Instituto de Investigacion Hospital Universitario La Paz
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Elena Izquierdo
Universidad CEU San Pablo Facultad de Medicina
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Frida Lind-Holm Mogensen
Luxembourg Institute of Health
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Alessandro Michelucci
Luxembourg Institute of Health
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Petr V. Nazarov
Luxembourg Institute of Health
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Simone P. Niclou
Luxembourg Institute of Health
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Giuseppe Nocentini
Universita degli Studi di Perugia Dipartimento di Medicina e Chirurgia
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Markus Ollert
Luxembourg Institute of Health Department of Infection and Immunity
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Matthias Preusser
Medical University of Vienna
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Nataliya Rohr-Udilova
Medical University of Vienna
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Andrea Scafidi
Luxembourg Institute of Health
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Reka Toth
Luxembourg Institute of Health
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Mieke Van Hemelrijck
King's College London School of Cancer & Pharmaceutical Sciences
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Michael Weller
UniversitatsSpital Zurich Neurologische Klinik
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Uta Jappe
Forschungszentrum Borstel Leibniz Lungenzentrum
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Maria Escribese
Universidad CEU San Pablo Facultad de Medicina
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Erika Jensen-Jarolim
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Sophia Karagiannis
King's College London School of Basic & Medical Biosciences
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Aurelie Poli
Luxembourg Institute of Health

Corresponding Author:[email protected]

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Abstract

Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and glioma. Allergic disease stems from a Th2-biased immune response to allergens in predisposed atopic individuals. Allergic disorders vary in phenotype, genotype, and endotype, affecting their pathophysiology. Beyond clinical manifestation and commonly used clinical markers, there is ongoing research to identify novel biomarkers for allergy diagnosis, monitoring, severity assessment, and treatment. Gliomas, the most common and diverse brain tumours, have in parallel undergone changes in classification over time, with specific molecular biomarkers defining glioma subtypes. Gliomas exhibit a complex tumour-immune interphase and distinct immune microenvironment features. Immunotherapy and targeted therapy hold promise for primary brain tumour treatment, but require more specific and effective approaches. Animal studies indicate allergic airway inflammation may delay glioma progression. This collaborative European Academy of Allergy and Clinical Immunology (EAACI) and European Association of Neuro-Oncology (EANO) Position Paper summarizes recent advances and emerging biomarkers for refined allergy and adult-type diffuse glioma classification to inform future epidemiological and clinical studies. Future research is needed to enhance our understanding of immune-glioma interactions to ultimately improve patient prognosis and survival.
09 Nov 2023Submitted to Allergy
09 Nov 2023Submission Checks Completed
09 Nov 2023Assigned to Editor
09 Nov 2023Review(s) Completed, Editorial Evaluation Pending
10 Nov 2023Reviewer(s) Assigned