Mitral valve abscess is a well-known complication of infective endocarditis, often requiring surgical treatment. Usually, the most typical localization is postero-lateral mitral annulus or mitral-aortic curtain at the base of the anterior leaflet in aortic valve endocarditis. We describe a 64-year-old male diagnosed with the abscess on the free margins of the mitral leaflets secondary to concomitant vertebral osteomyelitis. A favorable resolution of the abscess during the intravenous dual antibiotic therapy is presented.